Huang, W., Tang, L., Shi, Y., Huang, S., Xu, L., Sheng, R., Wu, P., Li, J., Zhou, N. and Hu, Y. (2011) Searching for the Multi-Target-Directed Ligands against Alzheimer’s Disease: Discovery of Quinoxaline-Based Hybrid Compounds with AChE, H 3 R and BACE 1 Inhibitory Activities. Bioorganic & Medicinal Chemistry, 19, 7158-7167.
http://dx.doi.org/10.1016/j.bmc.2011.09.061

has been cited by the following article:

• TITLE: Design, Synthesize and Bio-Evaluate 1,2-Dihydroisoquinolin-3(4H)-One Derivates as Acetylcholinesterase and β-Secretase Dual Inhibitors in Treatment with Alzheimer’s Disease

  AUTHORS: Youchao Deng, Yuren Jiang, Xiongjie Zhao, Jinlian Wang

  KEYWORDS: β-Secretase (BACE 1), Acetylcholinesterase (AChE), Inhibitor, Alzheimer’s Disease (AD)

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.4 No.1, January 26, 2016

  ABSTRACT: With the recent research advances in molecular biology and technology, many credible hypothe-ses about the progress of Alzheimer’s disease (AD) have been proposed, among which the amyloid and cholinergic hypotheses are commonly used to develop reliable therapeutic agents. The multitarget-directed ligand (MTDL) approach was taken in this work to develop multi-functional agents, which can mainly serve as dual BACE 1 and AChE inhibitors. Depending on the scaffolds of (+)-(S)- dihydro-ar-tumerone and (－)-gallocatechin gallate, 3 series of new compounds have been designed, synthesized and evaluated, from which we have identified 2-(2-(3-methylbenzoyl)-3-oxo-1,2,3,4- tetrahydroisoquinolin-6-yl) isoindoline-1,3-dione (3d) as a new cholinesterase and β-secretase dual inhibitor without toxicity. Furthermore, 3d also exhibits hydrogen peroxide scavenging activity which could help to reduce the reactive oxygen species (ROS) in the brain of AD patients.