TITLE:
Jobelyn®, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice
AUTHORS:
Solomon Umukoro, Osarume Omorogbe, Oritoke Modupe Aluko, Taghogho Anthony Eduviere, Olatunde Owoeye, Oluwafemi Gabriel Oluwole
KEYWORDS:
Jobelyn®, Unpredictable Chronic Mild Stress, Memory Performance, Oxidative Stress, Neuroprotection
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.5 No.13,
December
29,
2015
ABSTRACT: The ability of an organism to adapt to aversive stressful
situations or life challenging circumstances is very crucial to its state of health
and survival. However, breakdown in adaptation due to persistent uncontrollable
stress, leads to impairment of bodily functions and onset of a variety of pathological
disorders especially memory decline. This study was designed to evaluate the effect
of Jobelyn® (JB), a potent antioxidant sorghum-based food supplement
on unpredictable chronic mild stress (UCMS)-induced memory impairment in mice. Male
Swiss mice were given JB (5 - 50
mg/kg, p.o) 30 min prior to exposure to UCMS for 14 consecutive days before
testing for memory. Thereafter, the serum corticosterone level was estimated
by using ELISA kits. The levels of malondialdehyde (MDA) and glutathione (GSH) as well as acetylcholinesterase activity
were estimated in the brain homogenate using spectrophotometer. Histology of the
brain tissues and estimation of the populations of viable neurons in the hippocampal
region were done after staining with hematoxyline and eosin. Our results showed that JB reversed memory
impairment and suppressed corticosterone concentrations induced by UCMS. Moreover,
JB reduced oxidative stress in the brain of UCMS-mice as shown by decreased MDA levels and elevated GSH concentrations. It also decreased
brain acetylcholinesterase activity when compared with chronic stress group (p