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http://dx.doi.org/10.1016/S0003-4975(98)01098-4

has been cited by the following article:

• TITLE: Does the Animal Origin Influence the Calcification of Xenograft Tissue Heart Valve Substitutes? Comparison between Bovine and Camel Pericardium in a Subcutaneous Rat Model

  AUTHORS: Fatima Al Harmoodi, Salah Al Shafy, Michel Guichardant, Jean-Jacques Lebrun, Francoise Thivolet, Olivier Jegaden

  KEYWORDS: Pericardium, Calcification, Bovine, Camel, Xenograft Tissue, Heart Valve Substitutes

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.6 No.9, September 24, 2015

  ABSTRACT: Objective: To validate the hypothesis that camel pericardium could be more protected than bovine pericardium against calcification process according to the huge difference in their respective lifestyle and lifetime. Methods: Glutaraldehyde (GA) fixed bovine and camel pericardium samples (BP and CP respectively) were both implanted in 30 New Zealand white rats (2 BP and 2 CP matched specimens in each animal) and explanted after 60 days. Unimplanted GA-fixed samples of both species served as control. Matched implanted samples and unimplanted samples were randomly submitted to elemental analysis by spectroscopy, phospholipid extraction, macroscopic and X-ray examination and histology. Results: At 60 days, calcium and phosphorus content were respectively 9.54% ± 3.1% and 4.79% ± 1.4% of tissue dry weight in BP, and 12.52% ± 2.7% and 6.14% ± 1.3% of tissue dry weight in CP (ns). In X-ray analysis, the calcification score was 1.28 ± 0.45 and 2.14 ± 0.98 in BP and CP samples respectively without significant difference (p