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http://dx.doi.org/10.1172/JCI8253

has been cited by the following article:

• TITLE: Changes in Adenosine Metabolism in Asthma. A Study on Adenosine, 5'-NT, Adenosine Deaminase and Its Isoenzyme Levels in Serum, Lymphocytes and Erythrocytes

  AUTHORS: Jitender Sharma, Bala K. Menon, Vannan K. Vijayan, Surendra K. Bansal

  KEYWORDS: Asthma, Adenosine, Metabolism, Adenosine Deaminase, 5'-Nucleotidase

  JOURNAL NAME: Open Journal of Respiratory Diseases, Vol.5 No.2, March 19, 2015

  ABSTRACT: Background: Adenosine deaminase (ADA) and 5'-nucleotidase (5'-NT) play a crucial role in adenosine metabolism in healthy individuals. Adenosine is an inflammatory mediator of asthma. Changes in adenosine metabolism and role of ADA and 5'-NT in regulating adenosine level in asthmatics and correlation of these changes with severity of asthma are not clearly understood. Methods: In this study, we screened 5217 patients, of which 2416 were diagnosed with asthma. Further, of 2416 asthmatics, only 45 patients who strictly fulfilled the selection criteria were enrolled in the study. The patients were classified into mild, moderate and severe persistent groups; each group consisted of fifteen patients. Fifteen healthy subjects served as controls. Adenosine levels and activities of 5'-NT, total ADA, ADA1 and ADA2 in serum, lymphocytes and erythrocytes were determined. The data were analysed statistically and p vice versa.