TITLE:
Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes
AUTHORS:
Aroonsri Priprem, Pennapa Chonpathompikunlert, Saengrawee Sutthiparinyanont, Jintanaporn Wattanathorn
KEYWORDS:
Piperine Liposome; Anti-Depression Activity; Cognitive Enhancement Effect; Intranasal Route
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.2 No.2,
April
8,
2011
ABSTRACT: Antidepressant and cognitive effects of piperine -encapsulated liposomes (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body weight/day) and intranasal PL (7.2 µg/day) were randomly assigned to daily administer for 14 days to rats which were subjected to forced swimming, Mor-ris water maze and spontaneous motor behavior tests. PL significantly exhibited anti-depression like activity and cognitive enhancing effects, in comparison to the control groups after the first dose (p