TITLE:
Effects of Cyclopentolate on Form Deprivation Myopia in Guinea Pigs
AUTHORS:
Tao Li, Xiaodong Zhou, Zhi Chen, Xingtao Zhou
KEYWORDS:
Cyclopentolate, Muscarinic Antagonist, Form Deprivation Myopia, Axial Length, Refraction
JOURNAL NAME:
Open Journal of Ophthalmology,
Vol.5 No.1,
February
9,
2015
ABSTRACT: Purpose: To investigate the effects of intravitreal injection of cyclopentolate on form deprivation myopia in guinea pigs. Methods: Thirty-five guinea pigs at age of 3 weeks were randomly divided into 5 groups (n = 7 for each group): deprived, deprived plus saline, deprived plus cyclopentolate, normal control, and cyclopentolate group. Form deprivation was only performed in right eyes with translucent membranes for 4 weeks. Physiological saline and cyclopentolate were intravitreally injected into deprived eyes at four-day intervals. All the left eyes remained untreated as group control. Refraction was measured by retinoscopy after cycloplegia. The axial dimensions were measured by A-scan ultrasound. Subsequently, retinal histology was observed by light microscopy. Results: After 4 weeks of treatment, intravitreal injection of cyclopentolate significantly reduced the degree of myopia in the deprived eyes (from -3.92 D to -0.86 D, P