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http://dx.doi.org/10.1080/00397910802162934

has been cited by the following article:

• TITLE: Hydrolytic Degradation Study of Lansoprazole, Identification, Isolation and Characterisation of Base Degradation Product

  AUTHORS: Satyanarayana Battu, Vasudev Pottabathini

  KEYWORDS: Lansoprazole, Hydrolytic Degradation, Isolation, Characterization, Preparative HPLC, 1H NMR, 13C NMR and 2 D NMR

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.6 No.2, January 20, 2015

  ABSTRACT: Lansoprazole degradation is accelerated in both acidic and basic medium in water. The present investigation deals with the hydrolytic degradation of Lansoprazole. Acidic medium degradation show all known impurities and degradation products whereas basic degradation studies show new impurity which has higher molecular weight than Lansoprazole. New impurity was identified, isolated using mass based auto purification system and characterised by 1H NMR, 13C NMR, HMBC, HSQC, NOE, COSY and HRMS experiments. Isolated impurity was showing molecular weight of 467.10, molecular formula of C23H16F3N5OS and its name is 7-(3-Methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)-7H-benzo[4,5]imidazo[2,1-b]benzo[4,5]imidazo[2,1-d][1,3,5]thiadiazine.