TITLE:
Peste des Petits Ruminants Vaccine (Nigerian Strain 75/1) Confers Protection for at Least 3 Years in Sheep and Goats
AUTHORS:
Aamer Bin Zahur, Hamid Irshad, Aman Ullah, Muhammad Afzal, Asma Latif, Riasat Wasee Ullah, Umer Farooq, Muhammad Humayoon Samo, Muhammad Jahangir
KEYWORDS:
PPR Vaccine, Small Ruminants
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.2 No.6,
August
22,
2014
ABSTRACT:
The present study reports the duration of
immunity and protective efficacy of Peste des Petits Ruminants (PPR) vaccine
(Nigerian strain 75/1) in sheep and goats. A total of 105 sheep and goats were
divided into three groups A, B and C. Group A received normal recommended dose
(1.0 ml) of PPR vaccine, group B received half dose (0.5 ml) of PPR vaccine and
group C was kept as unvaccinated control group in contact with vaccinated
animals. The post vaccination dynamics of antibodies against PPR virus was studied.
It was found that significant antibody titres persisted for 3 years post
vaccination in sheep and goats vaccinated with either full dose or half dose of
PPR vaccine. The challenge protection studies were carried out in experimental
animals at 24 and 36 month post vaccination. The vaccinates withstood challenge
and were found completely resistant clinically and virologically to virulent
PPR virus for 24 and 36 months post vaccination. The unvaccinated control
animals developed typical clinical signs of PPR and the challenged virus was
detected in ocular, nasal and oral secretions of these animals. This study
demonstrated that a single immunization with PPR vaccine conferred solid
protection in sheep and goats for 3 years.