TITLE:
Status of Mycoplasma pneumoniae Pneumonia in Chinese Children: A Systematic Review
AUTHORS:
Qiang Qin, Baoping Xu, Xiuyun Liu, Kunling Shen
KEYWORDS:
Mycoplasma pneumoniae, Pneumonia, Chinese Children, Systematic Review
JOURNAL NAME:
Advances in Microbiology,
Vol.4 No.11,
September
4,
2014
ABSTRACT: Mycoplasma pneumoniae pneumonia (MPP)
becomes one of the most important health problems in China recently. Date for
MPP inChinais scarce. Although macrolides and/or cortical steroids had been reported to be
effective treatment for MPP, the long-term outcome remained uncertain. A study
on status of MPP in China was conducted via a systematic review of published
studies which have the Chinese data and collected from published PubMed and core
journals of China Knowledge Resource Integrated Database (CNKI). The analysis
was based on epidemiology, clinical characteristics, treatment, drug resistance
and prognosis. Twenty five articles concerned about MPP in Chinese children and
adolescent were enrolled, including 11 studies on epidemiology/etiology, 11
studies on clinical characteristics, 7 studies on drug resistance, 5 studies on
treatment from mainland China respectively. The overall incidence of MPP ranged
from 7.1% to 54.4%. Fever and cough were most frequently identified in
manifestations. Drug resistance to macrolides ranged from 18.9% to 90%. The outcome
of treatment in patients who received combined treatment of macrolides,
cephalosporin antibiotics and/or cortical steroid seems to be better than those
who received macrolides only. Macrolide combined with cephalosporin or cortical
steroid both may decrease the severity of MPP in the past decade. There was not
enough evidence to suggest that cortical steroid can decrease the mortality of
MPP in children. And a multi-center, randomized double blind research on the
effect of cortical steroid was encouraged.