TITLE:
Development of Melanoma and Cancer without Decreasing of Cambial Cells Number in Morphofunctional Zones
AUTHORS:
Tatiana M. Yavisheva, Sergey D. Shcherbakov
KEYWORDS:
Morphofunctional Zone at People of 20 - 60 Years Old, Tirosinase, Melanoma, Cancer
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.6,
May
9,
2014
ABSTRACT:
In
age groups from 20 to 60 years old, proliferation and differentiation of cells
happen in a morphofunctional zone, in the electric field excited by 12 pairs of
mother and daughter cells, turned out at cambial cells division. Thus in
daughter cells the Src SH2 domain necessary both for cytoskeleton formation and
tyrosinase activization is activated. If the conditions for strengthening of
tyrosinase activity are created in organism, the portion of Src participating
in the cytoskeleton building can decrease to critical level that will lead to
development of a malignant tumor. If action of a stimulating factor is quite
strong, proliferation of malignant cells begins at a stage of melanocyte, and a
melanoma occurs. If action of factors is long and not strong, more remote
descendants of daughter cells proliferate, and a cancer appears. In order that
there will be a normal differentiation of malignantly changed daughter cells,
it is necessary to block the tyrosinase. Thus all SH2 domains will go on cell
cytoskeleton formation.