Article citationsMore>>
Awan, Z., Choi, H.Y., Stitziel, N., Ruel, I., Bamimore, M.A., Husa, R., Gagnon, M.H., Wang, R.H., Peloso, G.M., Hegele, R.A., Seidah, N.G., Kathiresan, S. and Genest, J. (2013) APOE p.Leu167del Mutation in Familial Hypercholesterolemia. Atherosclerosis, 231, 218-222. http://dx.doi.org/10.1016/j.atherosclerosis.2013.09.007
has been cited by the following article:
-
TITLE:
Membrane Fluidity: About the Origin of Autoimmunity
AUTHORS:
Isolde Riede
KEYWORDS:
Membrane Fluidity; Autoimmunity; Essential Fatty Acids; Cholesterol; Protein Conformation
JOURNAL NAME:
Open Journal of Immunology,
Vol.4 No.1,
March
14,
2014
ABSTRACT: Fluidity of cellular membranes is essential for life. Two possibilities are known to keep human membranes fluid: unsaturated fatty acids and cholesterol. Whereas liver cells can synthesize cholesterol, unsaturated fatty acids are essential. Life style in Western civilization leads to deprivation of essential fatty acids, to elevated serum-cholesterol-levels and to autoimmunity. Here the hypothesis is presented, and explains the relationship: deprivation of essential fatty acids lead to imminent quasi-crystallization of the membrane. Serum cholesterol-levels are elevated. Incorporation of cholesterol into membranes enhancing fluidity again, is able to repair the effect. At saturation, repair fails. Quasi-crystallization occurs. Proteins tilt into another conformation. This has not been learned during the “self” recognition process of the immune system during the embryonic phase. Immune system attacks the new conformation as “non-self”, autoimmunity emerges.
Related Articles:
-
Cihan Akgul Ozmen, Deniz Gokalp, Hasan Nazaroglu, Ayfer Gozu Pirinccioglu
-
Rita Lourenço, Luísa Martins, João Anselmo, Marina Rita Soares, Ana Medeiros, Mafalda Bourbon, Rui César, Fernanda Gomes
-
Yan Liu, Alexandre Fisette, Marc Lapointe, Katherine Cianflone
-
Hui Zhou, Xiaoxiao Song, Bo Sun, Linjin Wu, Thachapol Napawan, Wei Gu
-
B. A. Diallo, E. M. Bah, O. H. Bah, I. Conté, I. K. Bah, I. S. Diallo, B. S. Diallo, I. S. Sow, S. Touré, D. Sidibé, M. D. Baldé