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Pisters, K.M., Evans, W.K., Azzoli, C.G., Kris, M.G., Smith, C.A., Desch, C.E., Somerfield, M.R., Brouwers, M.C., Darling, G., Ellis, P.M., Gaspar, L.E., Pass, H.I., Spigel, D.R., Strawn, J.R., Ung, Y.C. and Shepherd, F.A. (2007) Cancer Care Ontario and American Society of Clinical Oncology Adjuvant Chemotherapy and Adjuvant Radiation Therapy for Stages I-IIIA Resectable Non-Small-Cell Lung Cancer Guideline. Journal of Clinical Oncology, 25, 5506-5518. http://dx.doi.org/10.1200/JCO. 2007.14.1226
has been cited by the following article:
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TITLE:
Feasibility Study for Biweekly Administration of Cisplatin plus Vinorelbine as Adjuvant-Chemotherapy for Completely Resected Non-Small Cell Lung Cancer Patients in a Japanese Population
AUTHORS:
Shuichi Tsukamoto, Koji Yamazaki, Ryo Mori, Masakazu Katsura, Hidenori Kouso, Daigo Kawano, Chie Ushijima, Sadanori Takeo
KEYWORDS:
NSCLC; Adjuvant Chemotherapy; Cisplatin and Vinorelbine; Biweekly
JOURNAL NAME:
Advances in Lung Cancer,
Vol.3 No.1,
February
18,
2014
ABSTRACT:
Purpose: To evaluate the feasibility of
biweekly administration of cisplatin and vinorelbine as adjuvant chemotherapy
for patients with completely resected non-small cell lung cancer (NSCLC). Patients
and Methods: This was a single-arm, single-institutional study. Patients with
completely resected NSCLC (p-Stage IB-IIIA) with no previous chemotherapy or
radiotherapy were eligible. Simon’s optimal two-stage design was applied. Both
cisplatin (50 mg/m2) and vinorelbine (25 mg/m2) were
given on days 1 and 15, every 28 days. The primary endpoint of this study was
the feasibility of this combination in the four cycles of treatment. Results: Twenty patients (19 lobectomies and 1
pneumonectomy) were enrolled in this study. 10 (50%) of patients had
grade 3/4 neutropenia, and 3 (15%) had grade 3/4 anemia. Severe non-hematologic
toxicities were uncommon in this series. No treatment-related death was
encountered. 18 (90%) patients completed the planned 4 cycles of chemotherapy.
The median intensity was 24.3 (range 18.1 to 25) mg/m2/week with an
average of 23.6 (21 - 25) mg/m2/week cisplatin and 12.5
(range 10 to 12.5) mg/m2/week
with an average of 12.3 (10 - 12.5) mg/m2/week vinorelbine. The
median relative dose intensity of cisplatin was 97.5% (range 72.5% to 100%) with an average of 94.6% (72.5% - 100%) and that of vinorelbine was 100% (range 80% to 100%) with an average of 97.8% (80% - 100%). Conclusion: This regimen is feasible in the
treatment of patients with completely resected NSCLC. A phase III trial is warranted to assess the efficacy of this
regimen at promoting survival and preventing recurrence.
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