TITLE:
Analysis on Influential Factors for Anti-Infection Efficacy of Fluoroquinolones
AUTHORS:
Nan Wang, Liqin Zhu, Xuequn Zhao, Ying Yang
KEYWORDS:
Fluoroquinolones (FQNS); Antibiotics; Influential Factors; Ordinal Regression
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.1,
January
23,
2014
ABSTRACT:
Objective: To investigate factors contributed to anti-infection efficacy
of fluoroquinolones (FQNS), and ultimately to provide guidelines for the
application of such drugs. Methods: Clinical data of 519 infected patients who
were treated with fluoroquinolones were analyzed retrospectively. According to
the therapeutic efficacy of the drugs, cases were divided into 3 groups:
clinical inefficient, improved and cured. 11 potential factors were
investigated. The data were analyzed through logistic regression analysis to
determine the main factors which influence therapeutic effects. Results: Ordinal logistic regression revealed that age (OR = 0.979, 95% CI: 0.969, 0.989), a variety of medicine (moxifloxacin-OR = 3.465, 95% CI: 1.396, 8.601;
levofloxacin-OR = 4.605, 95% CI: 1.971, 10.760; ciprofloxacin-OR = 3.220, 95% CI:
1.089, 9.552; compared to lomefloxacin) (levofloxacin-OR = 2.591, 95% CI:
1.130, 5.944; compared to fleroxacin) and site of infection (respiratory system-OR = 3.016, 95% CI:
1.737, 5.236; urological system-OR = 4.077, 95% CI: 1.981, 8.391; digestive system-OR = 3.740, 95% CI: 1.849, 7.565) are main
factors which influence the efficacy. Conclusion: Fluoroquinolones
are more effective in the treatment of bacterial infection within drug’s indications
in young population. Variety, dosage and intervals of the drugs should be
adjusted according to disease condition.