TITLE:
Hepatoprotective Effect of Green Tea Extract against Cyclophosphamide Induced Liver Injury in Albino Rats
AUTHORS:
Ali Hassan A. Ali
KEYWORDS:
Green Tea, Albino Rats, Liver, Cyclophosphamide
JOURNAL NAME:
Forensic Medicine and Anatomy Research,
Vol.6 No.2,
April
13,
2018
ABSTRACT: Background: Green tea intake is accompanied with a lower incidence of cardiovascular disease, cancer and neurodegenerative disorders; hence green tea extract has been included as dietary supplement along with other supplements and multivitamins. Aim of the Work: Studying the effect of cyclophosphamide administration on the liver of adult male albino rats and the possible protective role of green tea extract. Material and Methods: The current study was carried out on 45 adult male albino rats. They were divided into three equal groups (each included 15 rats). Group I (control group) was injected intraperitoneally with normal saline at a dosage of 0.5 mg/kg body weight twice weekly for 9 weeks. Group II was injected intraperitoneally with cyclophosphamide (CP) (150 mg/kg/day) for two weeks. Group III: rats received green tea extracts orally (50 mg/kg/day) for three weeks, and then continued for further two weeks concomitantly with intraperitoneally cyclophosphamide (CP) injected (150 mg/kg/day). Results: Rats exposed to cyclophosphamide (CP) showed several histological and histochemical changes in their liver. These changes were improved by using green tea. Conclusion: The present work showed that green tea had preventive and therapeutic effect upon livers of albino rats after they were exposed to CP.