TITLE:
Effect of Albendazole and Mebendazole on Hydatid Cyst of Mice
AUTHORS:
Ekram Ismail Fagiree Ismail, Mohammed Bahaa Eldeen Ahmed Saad, Aisha Abass Elsadig
KEYWORDS:
Hydatid Cyst, Mebendazole, Albendazole
JOURNAL NAME:
Open Journal of Epidemiology,
Vol.7 No.4,
October
17,
2017
ABSTRACT: In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p