TITLE:
Nanomaterials and Cell Interactions: A Review
AUTHORS:
Tenderwealth Clement Jackson, Bernard Opatimidi Patani, Mary Blessed Israel
KEYWORDS:
Nanotoxicology, Nanomaterials, Cell, Cytotoxicity, Oxidative Stress, Genotoxicity
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.8 No.4,
September
21,
2017
ABSTRACT: Nanotoxicology, a branch of bionanoscience focuses on the study of the hazardous interactions between nanomaterials and the
ecosystem and ascertaining its consequent implications. Nanomaterial-cell
interactions are dependent on numerous factors such as size, shape, type and
surface coatings/charge of nanomaterials. These factors in association with
cell membrane factors such as charge and formation of the protein corona
influence the uptake and internalization of these particles leading to their
potential toxicity. Understanding the different routes of exposure, their
transport, behaviour and eventual fate is also
of importance. Toxicities that occur to the living systems are consequences
of various causes/dysfunctions such as ROS production, loss of membrane integrity, releases of toxic metal ions that bind
with specific cell receptors and undergo certain conformations that
inhibit normal cell function resulting in cytotoxicity, genotoxicity and
possible cell necrosis. This paper attempts to review the available research
pertaining to nanomaterial-cell interactions and their potential toxicity.