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https://doi.org/10.1507/endocrj.EJ16-0108

has been cited by the following article:

• TITLE: Pathophysiology of Graves’ Ophthalmopathy: A Literature Review

  AUTHORS: Mariela Carolina Santos Carballo, Bianca Paiva Cunha de Sá, Denise Rosso Tenório Wanderley Rocha, Alberto Krayyem Arbex

  KEYWORDS: Ophthalmopathy, Graves Disease, Pathophysiology

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.7 No.1, January 17, 2017

  ABSTRACT: Graves’ ophthalmopathy (GO), an autoimmune condition associated with Graves’ disease (GD), occurs at a prevalence of nearly 40% in patients diagnosed with GD. Ocular involvement is probably due to the presence of autoantibodies in the orbital tissues, regardless of the control state of thyroid hormones in individuals with GD, even during euthyroid or hypothyroid states, which are associated with thyroid hormone treatment. In addition to the immunological role present in the pathophysiology of GO, the genetic component, proteins and cytokines, minerals (e.g., selenium), and environmental factors (e.g., smoking) also contribute to its development and occurrence of clinical manifestations in varying degrees. Until now, the interaction of causal, intermediary, and triggering factors of GO is still unclear, so the purpose of this article is to review literature on the theme.