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Article citations


Bot, I., de Jager, S.C., Zernecke, A., Lindstedt, K.A., van Berkel, T.J., Weber, C. and Biessen, E.A. (2007) Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice. Circulation, 115, 2516-2525. doi:10.1161/01.ATV.14.9.1480

has been cited by the following article:

  • TITLE: Anti eotaxin-2 antibodies attenuate the initiation and progression of experimental atherosclerosis

    AUTHORS: Adi Mor, Arnon Afek, Michal Entin-Meer, Gad Keren, Jacob George

    KEYWORDS: Atherosclerosis; Vulnerable Plaque; Inflammation; Eotaxin-2; Chemokines

    JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.3 No.4, July 18, 2013

    ABSTRACT: Background: The chemokine eotaxin-2 is a potent chemoattractant for inflammatory cells, the predominants of which are eosinophils. Human and murine atherosclerotic plaques are known to exhibit inflammatory phenotypes where a complex interaction of cytokine and chemokines plays a role. We tested the hypothesis that eotaxin-2 (eo-2) plays a causative role in the initiation and progression of experimental atherosclerosis. Methods and Results: Sera collected from atherosclerotic ApoE knockout (KO) mice, exhibited significantly higher levels of eo-2 compared to sera collected from their background age matched C57BL/6 litters by ELISA. Moreover, levels of eo-2 were higher in old atherosclerotic ApoE KO mice than in young animals. Similarly, the expression level of the eo-2 receptor, CCR3, was increased in splenocytes of old ApoE compared to the young littermates. Administration of polyclonal blocking antibodies to eotaxin-2 resulted in a significant reduction of early atherosclerotic plaques in ApoE KO mice whereas prolonged treatment of mice with advanced plaques led to atheroma stabilization. A monoclonal antibody (D8) prepared against eo-2 attenuated adhesion of lymphocytes to fibronectin and potently inhibited their migration towards VEGF. Monoclonal blocking antibodies to eo-2 also significantly reduced atherosclerotic plaques in ApoE KO mice. Conclusion: Eo-2 serum levels are elevated in sera of ApoE KO mice with experimental atherosclerosis and its blockade is associated with reduced fatty streak accumulation and increased plaque stabilization.