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M. Valko, H. Morris and M. T. D. Cronin, “Metals, Toxicity and Oxidative Stress,” Current Medicinal Chemistry, Vol. 12, No. 10, 2005, pp. 1161-1208. doi:10.2174/0929867053764635

has been cited by the following article:

  • TITLE: Changes in Activity of Three Sulfurtransferases in Response to Exposure to Cadmium, Lead and Mercury Ions

    AUTHORS: Marta Kaczor-Kamińska, Piotr Sura, Maria Wróbel

    KEYWORDS: Sulfurtransferases; Heavy Metal Ions; Oxidative Stress

    JOURNAL NAME: Journal of Environmental Protection, Vol.4 No.6A, June 25, 2013

    ABSTRACT: Cadmium, lead and mercury are environmentally persistent toxicants that affect tissues and cellular components or exert an effect on generation of reactive oxygen species causing a decreased level of available antioxidant reserves. Sulfurtransferases are enzymes that are widespread in nature. Rhodanese, 3-mercaptopyruvate sulfurtransferase and γ-cystathionase play an important role in the metabolism of L-cysteine. Heavy metal ions can bind to -SH groups of cysteine residues in their active sites and, therefore, decrease the activity of these enzymes and result in changes in the level of sulfane sulfur-containing compounds, products of L-cysteine desulfuration. Changes in the activity of sulfurtransferases were investigated in the kidneys, heart, brain, liver and skeletal muscle of Marsh frogs (Pelophylax ridibundus) after 10 days of exposure to Pb(NO3)2 at the concentration of 28 mg/L and CdCl2 at the concentration of 40 mg or 80 mg/L, and in Xenopus laevies tissues after 7 and 14 days of exposure to HgCl2 at the concentration of 1.353 mg/L. The investigated heavy metal ions have a tendency to inhibit the activity of sulfurtransferases and decrease the level of glutathione, what can result in oxidative stress and oxidation of cysteine -SH groups to -SOH. This reversible oxidation and reduction of these redox sensitive groups can play a role in defenses against oxidative stress. Based on the presented results, one can surmise that also the expression of the three sulfurtransferases depends on heavy metal ions and/or some parameters of oxidative stress, what can explain the increase of the activity of MPST and CST in the kidney.