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Leibowitz, D. (1998) Epstein-Bar virus and a cellular signaling pathway in lymphomas from immunosuppressed patients. New England Journal of Medicine, 338, 1413-1421. doi:10.1056/NEJM199805143382003

has been cited by the following article:

  • TITLE: Myelodysplastic syndrome (MDS) associated with EBV infection in a pediatric patient

    AUTHORS: Esther Manor, Yonat Shemer-Avni, Sophia Boriakovski, Michael Kafka, Lipa Bodner, Joseph Kapelushnik

    KEYWORDS: Pediatric, MDS, EBV Infection

    JOURNAL NAME: Open Journal of Pediatrics, Vol.3 No.1, March 21, 2013

    ABSTRACT: Background: Epstein Barr Virus (EBV) is associated with different kinds of tumors. In the present study we tried to understand its role in pediatric MDS of a 4-year-old girl with EBV infection and MDS with refractory anemia and monosomy 7. Procedures: The work-up included: hematological tests; serology for IgM, IgG antibodies to EBV; PCR for EBV; cytogenetics of bone marrow (BM), and FISH analysis of BM and blood; immunohistochemistry-LMP1 expression on BM smears. Results: Hematological follow up showed constant mild dysplastic changes mostly in the erythroid lineage. PCR for EBV showed positive results in the nasopharygeal smears as well as in blood 15 weeks after disease onset. Cytogenetic analysis showed monosomy7 inall the mitoses of BM sample. Fluorescence in situ hybridization (FISH) showed monosomy 7% in 57% of the cells, followed by a decreased tendency in the percentage of monosomy 7 cells in both BM and blood. Immunohistochemistry for EBV-latent membrane protein 1 (LMP-1) on the patient’s BM smears, 21 weeks post disease onset, showed 9% positive cells, 80% of them carried monosomy 7. Conclusion: The parallel occurrence of the EBV infection and MDS, as well as the continuous EBV PCR positive and monosomy 7, support the possibility that they are related.