P. C. Taylor, A. M. Peters, E. Paleolog, et al., “Reduction of Chemokine Levels and Leukocyte Traffic to Joints by Tumor Necrosis Factor Alpha Blockade in Patients with Rheumatoid Arthritis,” Arthritis & Rheumatism, Vol. 43, No. 1, 2000, pp. 38-47. doi:10.1002/1529-0131(200001)43:1<38::AID-ANR6>3.0.CO;2-L

has been cited by the following article:

• TITLE: Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells

  AUTHORS: Delira Robbins, Wenjuan Li, Katie Humphrey, Yunfeng Zhao

  KEYWORDS: Ref-1; Tumorigenesis; JB6 Cells; Tumor Promotion; Chemoprevention

  JOURNAL NAME: Open Journal of Apoptosis, Vol.1 No.3, October 26, 2012

  ABSTRACT: Recently, redox factor-1 (Ref-1) has received considerable attention as an enzyme for stimulating tumor cell growth. We hypothesized that Ref-1 is upregulated during the early stage of tumorigenesis. Utilizing both tumor promotion sensitive P+ and promotion resistant P? mouse skin epidermal JB6 cells, we found that Ref-1 expression was only induced in tumor promotion sensitive P+ cells following TPA treatment. Consistent with that, Ref-1 knockdown suppressed skin cell transformation. Interestingly, Ref-1 knockdown suppressed nuclear translocation of NF-kappaB subunit p65, and inhibited production of proinflammatory cytokines. These results suggest Ref-1 may promote early tumorigenesis and serve as a target for chemoprevention.