Article citationsMore>>
Bournet, B., Souque, A., Senesse, P., Assenat, E., Barthet, M., Lesavre, N., Aubert, A., O’Toole, D., Hammel, P., Levy, P., Ruszniewski, P., Bouisson, M., Escourrou, J., Cordelier, P. and Buscail, L. (2009) Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis. Endoscopy, 41(6), 552-557.
has been cited by the following article:
-
TITLE:
Promoter hypermethylation of tissue specific tumor supressor genes and point mutation in K-ras, c-myc proto-oncogenes in urinary (transitional cell) bladder carcinoma
AUTHORS:
Oztürk Ozdemir, Esin Yildiz, Semih Ayan, Eylem Gul, Gökhan Gokce, Fazilet Yildiz, Binnur Koksal
KEYWORDS:
C-myc; K-ras; Ki-67; Urinary Bladder; Urothelial Neoplasms; Promoter Hypermethylation; Tumor Supressor Genes
JOURNAL NAME:
Health,
Vol.2 No.8,
August
25,
2010
ABSTRACT: In a total of 83 UN specimens were investigated for proto-oncogene mutations, tumor supressor genes promoter methylation status and c-myc and Ki-67 expression. Point mutations in c-myc were detected in cases with high grade and proliferation index. Mutated K-ras proto-onco- gene profiles were detected in 17 (21%) tumoral spiecemens that examined. Tumor specimens were also showed hypermethylated promoter domain for the SFRP2, MGMT tumor supressor genes. These findings showed the combine effect of mutated c-myc and K-ras oncogene and epigenetic inactivation of tissue specific tumor supressor genes (TS) play a crucial role in tumor progression and recurrence in UN carcinogenesis.
Related Articles:
-
Mirwais Rashid
-
Abdellatif Bouzidi, Ahmed S. Bouazzi, Mosbah Amlouk
-
Sándor Szabó
-
P. Jagdish, N.P. Rajesh, S. Natarajan
-
Rose E. Constantino, Ayman M. Hamdan-Mansour, Amanda Henderson, Bonnie Noll-Nelson, Willa Doswell, Betty Braxter