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Kok, S.H., Cheng, S.J., Hong, C.Y., et al. (2005) Norcan-tharidin-Induced Apoptosis in Oral Cancer Cells Is Associated with an Increase of Proapoptotic to Antiapoptotic Protein Ra-tio. Cancer Lett., 217, 43-52. https://doi.org/10.1016/j.canlet.2004.07.045

has been cited by the following article:

  • TITLE: N-Methylcantharidinimidum Induces Apoptosis in Human Hepatocellular Carcinoma Cell HepG2

    AUTHORS: Li Tang, Yi Shen

    KEYWORDS: N-Methylcantharidinimidum, HepG2, Apoptosis, HCC

    JOURNAL NAME: Journal of Biosciences and Medicines, Vol.7 No.5, May 17, 2019

    ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the prognosis of patients was poor. Cantharidin is an effective anti-tumor component of Chinese traditional medicine. N-methylcantharidinimidum is a novel cantharidin derivative with better curative effect and less side effect. In this study, the effects of N-methylcantharidinimidum on proliferation, apoptosis and cell cycle of human hepatocellular carcinoma cell line HepG2 were examined. The results demonstrated that N-methylcantharidinimidum significantly induced apoptotic cell death in a dose and time-dependent manner and arrested cell cycle in HepG2 cells. N-methylcantharidinimidum also suppressed cyclin D1. This study suggests that N-methylcantharidinimidum may serves as a potential chemopreventive agent for live cancer.