TITLE:
CRKL and CK2 β over Expression Are Independent Predictors of Patients Survival in Endometrioid Endometrial Carcinoma
AUTHORS:
Randa Mohamed Kaf, Wafaa El-Beshbishi, Ahmed A. Obaya, Rham Z. Ahmed, Khaled Fathy Helal, Mohamed SH. Ramadan, Abdelwahab S. Almoregy, Ibrahim A. Heggy, Ola A. Harb
KEYWORDS:
CRKL, CK2 β, Endometroid Carcinoma, Immunohistochemistry, Prognosis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.4,
April
16,
2019
ABSTRACT: Context: The prognostic significance of expression of V-Crk
avian sarcoma virus CT10 oncogene homolog-like
(CRKL) and Protein kinase CK2 β in
endometroid carcinoma is not fully clarified. Aim: To assess the prognostic values and
clinicopathological roles of CRKL and CK2 β expression in endometroid carcinoma by correlation their expression
levels with clinicopathological parameters,
response to therapy, and recurrence of the tumor and patients survival. Settings: Faculty of Medicine,
Zagazig University, and Mansoura University. Methods: CRKL and CK2 β expressions were
evaluated in 50 paraffin blocks EC patients that were followed up for 5 years.
The relationship between their level of expressions, clinicopathological
criteria and prognosis of patients was analyzed. Statistical
analysis used: SPSS 22.0 for windows (SPSS Inc., Chicago, IL, USA)
and MedCalc windows (Software bvba 13, Ostend, Belgium). Results: High expression of CRKL and CK was positively correlated with higher
grade of the tumor (p = 0.004 and 0.006
respectively), presence of L.N metastases (p = 0.009 and 0.003
respectively), presence of distant metastases (p = 0.029
and 0.003 respectively) and advanced FIGO stage (p 0.001),
poor response to therapy (p = 0.046 and 0.005 respectively), higher incidence of recurrence of the tumor after therapy (p = 0.004 and 0.048 respectively), higher incidence of cancer progression p = 0.018
and 0.044 respectively), poor PFS (p = 0.008
and 0.013 respectively), and OS rates (p