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https://doi.org/10.1371/journal.pone.0166758

has been cited by the following article:

• TITLE: Plasma Levels of Amino Acids in Japanese Men and Their Changes after the Administration of Glucose and Sucrose

  AUTHORS: Akikazu Takada, Fumiko Shimizu, Yukie Ishii, Mutsumi Ogawa, Tetsuya Takao

  KEYWORDS: Amino Acids, Branched Chain Amino Acids, Tryptophan, Serotonin, Leucine, Appetite, Feeding

  JOURNAL NAME: Food and Nutrition Sciences, Vol.10 No.1, January 14, 2019

  ABSTRACT: Background: It is not known whether plasma amino acids levels are different between young and old men in Japan. No research has been reported about changes in plasma levels of amino acids after the administration of glucose or sucrose to young and aged men. Objective: We want to know whether there are age differences in plasma levels of amino acids and if the administration of glucose or sucrose influences their levels. Results: Old people had lower plasma levels of most of amino acids, especially essential and branched-chain amino acids than young men. Plasma levels of amino acids were measured after the administration of 50 grams of glucose or sucrose to young (18 - 22 years old) and aged (≥50 years old) male adults. Plasma levels of total amino acids decreased after the administration of glucose. Decrease in the total amino acid levels was significant in aged men after the administration of sucrose. A significant decrease in plasma levels of total non-essential amino acids was observed at 120 min after the administration of glucose but not sucrose in both aged and young men. Both glucose and sucrose administrations resulted in a significant decrease in the plasma levels of the total essential amino acid levels and branched amino acids in young and aged men. Conclusion: These results suggest that there are age differences in plasma levels of amino acids. Upon the administration of glucose or sucrose amino acids, particularly essential amino acids, decreased in plasma. These amino acids may be transported from the blood soon after the administration of sugar (glucose or sucrose) to the tissues, such as muscles, possibly due to an increase in the insulin levels.