TITLE:
Numerical Study on the Relationship between the Number of Ferritin Subunits and the Size of Outer Diameter
AUTHORS:
Xinye Zhao, Junhui Gao
KEYWORDS:
Ferritin, Outer Diameter, Number of Strands, Sequence Similarity, Evolutionary Tree
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.9 No.10,
October
16,
2018
ABSTRACT: Ferritin is assembled from
sub-chains into a spherical shape. We have found that the number of sub-chains is
generally 3, 6, 8, 12, 24, 36, and the corresponding spherical volume (outer
diameter) is also different. In this paper, using the protein structural data
from PDB website, linear regression was carried out to model the relationship
between sub-chain number and outer diameter of 25 ferritins by calculation and
analysis, but the results were not ideal. In order to improve the model, we
divided the 25 proteins into two groups by molecular evolution, followed by the
establishment of a linear model. The correlation coefficient of one group was R2 = 0.98. Based on calculations and modelling, we hypothesize that the new
ferritin formed by the 3kx9
site-directed mutagenesis is no longer 24-chain, but a 36-chain mutant.