Duma, C.M., Kim, B.S., Chen, P.V., Plunkett, M.E., Mackintosh, R., Mathews, M.S., Casserly, R.M., Mendez, G.A., Furman, D.J., Smith, G., Oh, N., Caraway, C.A., Sanathara, A.R., Dillman, R.O., Riley, A.S., Weiland, D., Stemler, L., Cannell, R., Abrams, D.A., Smith, A., Owen, C.M., Eisenberg, B. and Brant-Zawadzki, M. (2016) Upfront Boost Gamma Knife “Leading-Edge” Radiosurgery to FLAIR MRI-Defined Tumor Migration Pathways in 174 Patients with Glioblastoma Multiforme: A 15-Year Assessment of a Novel Therapy. Journal of Neurosurgery, 125, 40-49.

has been cited by the following article:

• TITLE: Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments

  AUTHORS: M. A. Nezami, Christopher Duma

  KEYWORDS: Quercetin, Glioblastoma, Leading Edge Gamma Knife

  JOURNAL NAME: Journal of Cancer Therapy, Vol.9 No.6, June 29, 2018

  ABSTRACT: The Stupp protocol has become standard of care for the treatment of glioblastoma (GBM) (since its publication in 2005) and has led to some limited survival improvements. This protocol, consists of radiotherapy and concomitant chemotherapy with temozolomide, an alkylating agent. Temozolomide + radiation, compared to radiation alone had added in average 3 months additional life span, 16 percent improved survival at 2 years. That said since 2005, the standard of care has not changed in regards to the treatment of early diagnosed aggressive or multifocal GBM, and unfortunately the expected survival is still poor with 75 percent of patients dying in less than 2 years and average survival of 15 months. In patients with multifocal tumors (such as the case below) the average survival is even worse with less than 4 months at her age [1]. Here we present a case study of a patient with advanced multifocal, and rapidly progressing Glioblastoma Multiforme treated with STUPP protocol in combination with IV Quercetin. The patient experienced improved quality of life and response, compared to historical data. It is our recommendation to investigate such combinational approach in patients with Glioblastoma, as in our case it proved to be safe and effective with improved quality of life and performance as well as clinical response and survival.