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Sauer, R. et al. (2004) Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer. The New England Journal of Medicine, 351, 1731-1740.
https://doi.org/10.1056/NEJMoa040694

has been cited by the following article:

  • TITLE: Preoperative Conformal Radiotherapy Concurrently with Paclitaxel/Carboplatin in Gastric Cancer

    AUTHORS: Shimaa Ahmed, Mayada Fawzy, Khalid Rezk, Wessam Elshrif, Mohamed Alaa, Mohamed M. H. Abd Ellah

    KEYWORDS: Gastric Adenocarcinoma, Neoadjuvant, Paclitaxel-Carboplatin, Chemoradiotherapy, Pathologicalcr-R0

    JOURNAL NAME: Journal of Cancer Therapy, Vol.9 No.6, June 25, 2018

    ABSTRACT: Background and objectives: Surgery is the primary therapy for localized gastric cancer, but even with the best results only 40% 5-year survival can be achieved with the use of postoperative adjuvant chemoradiotherapy. Preoperative therapy might help increase the R0 resection rate, which is an independent predictor of 5-year OS. Our study hypothesized that the concurrent combination of carboplatin-paclitaxel with radiation therapy would result in a pathological CR rate, which will be in turn associated with OAS and DFS benefits. Patients and methods: prospective phase II study included 32 patients with locally advanced gastric adenocarcinoma including gastroesophageal junction who received a combination of neoadjuvant conformal radiotherapy concurrently with carboplatin-paclitaxel followed by surgery. Results: Pathological CR and R0 resection rates were 18.8% and 75% respectively. With a median follow up of 24 months, 2 years disease-free survival was 28.1% and overall survival was 51.3%. The regimen was tolerated with neither grade 4 toxicities nor deaths. Conclusion: Neoadjuvant radiotherapy concomitant with carboplatin-paclitaxel chemotherapy is a well-tolerated approach for patients with locally advanced gastric adenocarcinoma resulting in significant pathological CR and R0 resection margins as reflected by the good DFS and OS.