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Lüscher, C., Tan, K.R. and Rudolph, U. (2011) Hooke on Benzodiazepines: GABAA Receptor Subtypes and Addiction. Trends in Neurosciences, 34, 188-197.
https://doi.org/10.1016/j.tins.2011.01.004

has been cited by the following article:

  • TITLE: Sex and Age-Related Differences in Neuroticism and Allostatic Load Index in Urban Patients with General Anxiety Disorder Treated with Alprazolam

    AUTHORS: Carlos A. Soria, Carolina Remedi, Luciana D’Alessio, Emilio J. A. Roldán

    KEYWORDS: Chronic Stress, Neuroticism, Alprazolam, Anxiety, Allostatic Load

    JOURNAL NAME: Open Journal of Psychiatry, Vol.8 No.3, June 19, 2018

    ABSTRACT: Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (−1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included; 28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods.