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Yorke, E.D., Fuks, Z., Norton, L., Whitmore, W. and Ling, C.C. (1993) Modelling the Development of Metastases from Primary and Locally Recurrent Tumors: Comparison with a Clinical Data Base for Prostatic Cancer. Cancer Research, 53, 2987-2993.

has been cited by the following article:

  • TITLE: Mathematical Models and Numerical Simulation for Dynamic Evolutions of Cancer and Immune Cells

    AUTHORS: Benjamin Oyediran Oyelami

    KEYWORDS: Model, Cancer, Numeric Simulation, Pollution, Carcinogenic

    JOURNAL NAME: Applied Mathematics, Vol.9 No.6, June 6, 2018

    ABSTRACT: Cancer is a major public health problem worldwide and finding a total cure or eradication of the disease has been the expectations of medical researchers and medical practitioners in the recent times. In this paper, invasion of normal cells by carcinogens is considered. The purpose of the research is to study the dynamic evolutions of cancer and immune cells with the view finding most effective strategic way to control or eradicate cancer growth in human beings. We proposed five growths and mitigate models for benign and malignant cancer which are coupled ordinary differential equations and partial differential equations and Numerical simulations are made for the models. Analytic and Numerical solutions and sensitivity analysis of the models to parameters are obtained. It is found that the benign and malignant cancer cells displayed out of control growth and hence unstable in nature and the immune cells depreciated to the point of immune collapse. By the use of energy function it is established that staving of cancer cells of oxygen or use of drugs are strategic ways of combating cancer disease. Moreover, if the cancer cells are starved of basic nutrients or some basic enzymes inhibited it is expected that similar effect can also be achieved. The starvation of cancer cells should focus on oxygen, nutrients and vital enzymes. However, it is hoped that drugs developers and bioengineers will come up with means to achieve the starvation strategies to combat cancer disease.