TITLE:
Application of Regional Arterial Infusion Chemotherapy in Advanced Gastric Cancer
AUTHORS:
Hao Xu, Weicheng Wang, Xiaoming Zhang, Yi Zhou, Jing Zheng, Cui Yang, Lin Yang
KEYWORDS:
Gastric Cancer, Neoadjuvant Chemotherapy, Regional Arterial Infusion Chemotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.9 No.2,
February
11,
2018
ABSTRACT: Gastric cancer ranks as the fifth most common
malignant tumor worldwide and is the third most common cause of cancer-related death.
For advanced gastric cancer (AGC), neoadjuvant chemotherapy (NAC) can reduce its
stage, increase the rate of radical resection, improve response to treatment, reduce
the risk of local recurrence and improve survival rate. Regional arterial infusion
chemotherapy (RAIC) is a form of NAC that involves directly injecting chemotherapeutic
drugs into the tumor site through the tumor-feeding artery. RAIC increases the local
drug concentration around the tumor, thereby improving the therapeutic responses
and reducing the adverse effects of the drugs. In recent years, RAIC has attracted
increasing attention. This article summarizes the basic principles, procedure, chemotherapy
regimens, adverse drug reactions and complications, clinical applications and response
evaluation of RAIC in the treatment of AGC.