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K. Shigemi, Y. Tsuneyoshi, S. Yamada, Y. Kabuki, K. Hayamizu, D. M. Denbow and M. Furuse, “Oral Administration of L-Serine Reduces the Locomotor Activity of Socially Isolated Rats,” Neuroscience Letters, Vol. 468, No. 1, January 2010, pp. 75-79. doi:10.1016/j.neulet.2009.10.068

has been cited by the following article:

  • TITLE: L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices

    AUTHORS: Kazutaka Shigemi, Koji Tanaka, Kohsuke Hayamizu, Donald Michael Denbow, Mitsuhiro Furuse

    KEYWORDS: L-Serine, Chick, Brain Slice, Taurine, L-Alanine

    JOURNAL NAME: Neuroscience and Medicine, Vol.2 No.3, September 28, 2011

    ABSTRACT: L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate anti-stress factor, the central mechanism of L-serine is not clear. The present study clarifies the action of L-serine using acute chick brain slices. We investigated the changes in some extracellular fluid amino acid concentrations in response to L-serine perfusion. Taurine concentration decreased while L-alanine concentration increased following L-serine perfusion. To examine the involvement of the taurine transporter, the effect of L-serine on the taurine concentration in the presence and absence of Na+ was also investigated. Na+ had no effect on taurine concentration induced by L-serine perfusion. These results suggest that L-serine has an ability to promote L-alanine synthesis facilitating the catabolism of taurine. In conclusion, L-serine modifies the metabolism of taurine and L-alanine in the extracellular space in chick brain.