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J. Jaeken, M. Detheux, L. Van Maldergem, M. Foulon, H. Carchon and E.Van Schaftingen, “3-Phosphoglycerate Dehydrogenase Deficiency: An Inborn Error of Serine Biosynthesis,” Archives of Disease in Childhood, Vol. 74, No. 6, January 1996, pp. 542-545. doi:10.1136/adc.74.6.542

has been cited by the following article:

  • TITLE: L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices

    AUTHORS: Kazutaka Shigemi, Koji Tanaka, Kohsuke Hayamizu, Donald Michael Denbow, Mitsuhiro Furuse

    KEYWORDS: L-Serine, Chick, Brain Slice, Taurine, L-Alanine

    JOURNAL NAME: Neuroscience and Medicine, Vol.2 No.3, September 28, 2011

    ABSTRACT: L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate anti-stress factor, the central mechanism of L-serine is not clear. The present study clarifies the action of L-serine using acute chick brain slices. We investigated the changes in some extracellular fluid amino acid concentrations in response to L-serine perfusion. Taurine concentration decreased while L-alanine concentration increased following L-serine perfusion. To examine the involvement of the taurine transporter, the effect of L-serine on the taurine concentration in the presence and absence of Na+ was also investigated. Na+ had no effect on taurine concentration induced by L-serine perfusion. These results suggest that L-serine has an ability to promote L-alanine synthesis facilitating the catabolism of taurine. In conclusion, L-serine modifies the metabolism of taurine and L-alanine in the extracellular space in chick brain.