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Raptopoulou, M., Touloumi, G., Tzourmakliotis, D., Nikolopoulou, G., Dimopoulou, M., Giannoulis, G. and Manolakopoulos, S. (2011) Significant Epidemiological Changes in Chronic Hepatitis C Infection: Results of the Nationwide HEPNET-GREECE Cohort Study. Hippokratia, 15, 26-31.

has been cited by the following article:

  • TITLE: Managing Hepatitis C Patients in Greece: A Budget Impact Analysis of Simeprevir plus Pegylated Interferon/Ribavirin Regimen at Early Stages of the Disease

    AUTHORS: Mary Geitona, Hara Kousoulakou, Ioannis Goulis, Spilios Manolakopoulos, Themistoclis Vasiliadis, Dimitrios Christodoulou, Charalabos Gogos, Spyridon Dourakis, Ioannis George Koskinas, Alexandra Papadokostopoulou, Aris Lathouris, George Papatheodoridis

    KEYWORDS: Hepatitis C, Budget Impact Analysis, Simeprevir, Greece

    JOURNAL NAME: Health, Vol.9 No.11, October 23, 2017

    ABSTRACT: Objectives: To identify local resource use such as pharmaceutical treatment, medical follow-up, and patient hospitalization and estimate the budget impact of simeprevir (SMV) plus pegylated interferon (P)/ribavirin (R) as a treatment option in the early stages of the disease in Greece. Methods: A budget impact tool was developed with a two-year time horizon, which estimated the impact on the Social Insurance Funds (SIFs) of introducing SMV + PR in the management of the early disease stages. Total direct and indirect costs were estimated for each of the following health states: non-cirrhotic chronic Hepatitis C (and within that by fibrosis stage), compensated cirrhosis, decompensated cirrhosis, and hepatocellular carcinoma. Data gaps on treatment algorithms, resource use and productivity losses were covered via an expert panel of eight leading hepatologists. Epidemiology data were taken from the published literature. Unit costs were obtained from the Ministry of Health and SIFs. The perspective was that of the SIF and the cost base year was 2015. Results: The total (direct and indirect) cost per patient per year (excluding cost of antiviral treatment) was estimated at €647, €703, €5,753, €16,313 and €37,237 for non-cirrhotic CHC, compensated cirrhosis, decompensated cirrhosis, HCC and liver transplantation, respectively. The budget impact analysis showed that adding SMV to PR in the early stages of the disease would lead to an increase in the cost of antiviral treatment by €2.03 million. Conclusions: Costs of managing CHC increase dramatically with disease severity. SMV + PR for naive patients at early disease stages has a significant but manageable budget impact, and could prevent high costs in advanced stages.