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has been cited by the following article:

• TITLE: Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base

  AUTHORS: Ramakrishna Vellalacheruvu, Ramayanam Sai Leela, L. K. Ravindranath

  KEYWORDS: Imidazole Analogues, Thiozolidine-2, 4-Dione Nucleus, Toluenesulfonylmethyl Isocyanide, Combi-Flash Column Chromatography

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.7 No.3, September 6, 2017

  ABSTRACT: The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.