TITLE:
Prognosis and Outcome of Adult Patients with Ewing Sarcoma (Local Experience)
AUTHORS:
Mohamed Ashour, Salem Al Shammari, Hanan Shafik, Ahmed Mohialdien
KEYWORDS:
Adult, Ewing, Sarcoma, Treatment
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.8 No.8,
August
8,
2017
ABSTRACT:
Objective: Aim of this work is to assess clinical features, outcome and prognosis
of adult patients diagnosed with Ewing Sarcoma (ES). Patients, Methods
and Results: The records of 53 adult patients treated with Euro-Ewing
protocol at Kuwait cancer control center (KCCC) over a period of 5 years
were reviewed. Mean age was 26.9 ± 1.25 years. Thirty percent of patients
presented with metastatic disease, and 65% of tumors were centrally located
and 50% were ≥ 8 cm. All patients received initially VIDE protocol. 13.5%
achieved complete remission (CR), and 57.7% achieved partial response (PR).
Approximately 1/3 of patients underwent surgery which was adequate in 76%
of them, and all patients received local radiotherapy. Post local treatment 56%
of patients received VAC and 44% received VAI protocol. Mean treatment
duration was 11 months ± 0.54. Median follow-up duration was 38.39 (33.49 -
43.28) months At the end of follow up 20% of patients relapsed locally and
36% distally. Median PFS was 46.9 months (95% CI 41.42 - 52.39), Median OS
was 55.43 ms (95% CI 30.71 - 75.74); survivals at 3 and 5 years were 88%, 46%
respectively. Conclusion: In this series metastases at presentation and wide
surgical margins were the most important prognostic factors. Multimodality
therapy is necessary for this rare disease.