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Article citations


Duzguner, V., Kucukgul, A., Erdogan, S., Celik, S. and Sahin, K. (2008) Effect of Lycopene Administration on Plasma Glucose, Oxidative Stress and Body Weight in Streptozotocin Diabetic Rats. Journal of Applied Animal Research, 33, 17-20.

has been cited by the following article:

  • TITLE: Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats

    AUTHORS: Ejike Daniel Eze, Yusuf Tanko, Ahmed Abubakar, Sheu Oluwadare Sulaiman, Karimah Mohammed Rabiu, Aliyu Mohammed

    KEYWORDS: Diabetes Mellitus, Streptozotocin, Lycopene, Erythrocyte Osmotic Fragility, Lipid Peroxidation, Rats

    JOURNAL NAME: Journal of Diabetes Mellitus, Vol.7 No.3, July 21, 2017

    ABSTRACT: Introduction: Diabetes mellitus has remained one of the serious health problems in the world; and oxidative stress has been reported to be a root cause for the progression and development of diabetes mellitus and its associated complications. Aim: This study investigated the possible ameliorative effects of lycopene on diabetic-induced changes in erythrocyte osmotic fragility and lipid peroxidation in Wistar rats. Methodology: The animals were made diabetic by single intraperitoneal injection of streptozotocin at 60 mg/kg b w. Diabetes was confirmed by the presence of high fasting blood glucose level ≥ 200 after 72 hours. Thereafter, diabetic rats were randomly assigned into six groups (1, 2, 3, 4, 5 and 6) comprising five animals each. Group 1 (Diabetic control) and group 2 (Normal control) rats received 0.5 ml of olive oil, groups 3, 4, 5 rats received 10, 20, 40 mg/kg bw of lycopene respectively, while those in group 6 received 2 mg/kg bw of glibenclamide orally once daily for a period of four weeks. At the end of the treatment, all animals were sacrificed; blood samples collected for determination of erythrocyte osmotic fragility (EOF) and lipid peroxidation (LPO). Results: The results obtained showed that there was a significantly (P Conclusion: From the available findings, it can be concluded that administration of lycopene to diabetic rats attenuated diabetic-induced changes in EOF and LPO and these observed effects may be attributed to anti-oxidative property of lycopene.