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Mackin, D., Zhu, X.R., Poenisch, F., et al. (2014) Spot-Scanning Proton Therapy Patient-Specific Quality Assurance: Results from 309 Treatment Plans. International Journal of Particle Therapy, 1, 711-720.
https://doi.org/10.14338/IJPT-14-00017.1

has been cited by the following article:

  • TITLE: Patient-Specific QA of Spot-Scanning Proton Beams Using Radiochromic Film

    AUTHORS: Maria F. Chan, Chin-Cheng Chen, Chengyu Shi, Jingdong Li, Xiaoli Tang, Xiang Li, Dennis Mah

    KEYWORDS: Proton Therapy, Patient-Specific QA, Gaf Chromic EBT3, Film Dosimetry

    JOURNAL NAME: International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, Vol.6 No.2, May 16, 2017

    ABSTRACT: Radiochromic film for spot-scanning QA provides high spatial resolution and efficiency gains from one-shot irradiation for multiple depths. However, calibration can be a tedious procedure which may limit widespread use. Moreover, since there may be an energy dependence, which manifests as a depth dependence, this may require additional measurements for each patient. We present a one-scan protocol to simplify the procedure. A calibration using an EBT3 film, exposed by a 6-level step-wedge plan on a Proteus®PLUS proton system (IBA, Belgium), was performed at depths of 18, 20, 24 cm using Plastic Water® (CIRS, Norfolk, VA). The calibration doses ranged from 65 - 250 cGy (RBE) (relative biological effectiveness) for proton energies of 170 - 200 MeV. A clinical prostate + nodes plan was used for validation. The planar doses at selected depths were measured with EBT3 films and analyzed using one-scan protocol (one-scan digitization of QA film and at least one film exposed to a known dose). The gamma passing rates, dose-difference maps, and profiles of 2D planar doses measured with EBT3 film and IBA MatriXX-PT, versus the RayStation TPS calculations were analyzed and compared. The EBT3 film measurement results matched well with the TPS calculation data with an average passing rate of ~95% for 2%/2 mm and slightly lower passing rates were obtained from an ion chamber array detector. We were able to demonstrate that the use of a proton step-wedge provided clinically acceptable results and minimized variations between film-scanner orientation, inter-scan, and scanning conditions. Furthermore, for relative dosimetry (calibration is not done at the time of experiment), it could be derived from no more than two films exposed to known doses (one could be zero) for rescaling the master calibration curve at each depth. The sensitivity of the calibration to depth variations has been explored. One-scan protocol results appear to be comparable to that of the ion chamber array detector. The use of a proton step-wedge for calibration of EBT3 film potentially increases efficiency in patient-specific QA of proton beams.