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Article citations


Christiansen, C., Pichler, W.J. and Skotland, T. (2000) Delayed Allergy-Like Reactions to X-Ray Contrast Media: Mechanistic Considerations. European Journal of Radiology, 10, 1965-1975.

has been cited by the following article:

  • TITLE: Safety and Diagnostic Image Quality of Ultravist® in an Unselected Sub-Set of Chinese Patients: Data Analyses from a Previous Post Marketing Surveillance

    AUTHORS: Shuixing Zhang, Changhong Liang, Ziping Li, Jary Wang

    KEYWORDS: Contrast Media, Iopromide, Adverse Drug Reaction, Chinese Sub-Population, Post-Marketing Surveillance

    JOURNAL NAME: Open Journal of Radiology, Vol.7 No.1, March 31, 2017

    ABSTRACT: Background: Iopromide (Ultravist®) has been shown to be a very safe CM agent in previous post-marketing surveillance studies on Western and Asian populations. Our study aimed to analyse data pertaining to the safety, tolerability and diagnostic image quality of Iopromide in an unselected sub-set of the Chinese population. Methods: we analysed data for Chinese ambulatory and in-patients who received Iopromide for an imaging procedure (in accordance with the local package insert and routine clinical practice), as part of an international post-marketing surveillance study. Use of premedication was at the discretion of the attending physician. Patient demographics, clinical history, type of examination, contrast quality and tolerability, including pre-specified adverse drug reactions, were recorded. All statistical analyses were descriptive. Results: case report forms for 20,000 Chinese patients (61.3% men) were analysed, of whom 153 patients (0.77%) had risk factors for idiosyncratic contrast media reactions (at-risk group). Use of premedication, most commonly corticosteroids, was recorded for 5658 patients (28.3%) and 86 at-risk patients (56.2% of the at-risk group), respectively. The mean (±standard deviation) dose of iodine administered was 29 ± 5.5 g. During the physician’s evaluation of image parameters, contrast quality was considered to be “good” (64.7%) or “excellent” (29.3%) in the majority of patients. 571 patients (2.9%) experienced at least one adverse drug reaction [most frequently nausea (0.70%) and dysgeusia (0.62%)], which were typically transient and of mild intensity. Two serious adverse drug reactions were reported [edema (n = 1), decreased blood pressure and dyspnea (n = 1)]. The incidence of adverse drug reactions was increased in the at-risk group versus the overall patient population, and tended to reduce with premedication (mainly corticosteroids). Conclusions: Iopromide was well tolerated and proved to be an efficient contrast agent in a large, non-selected sub-set of Chinese patients undergoing different types of diagnostic imaging procedures.