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Sharew, B., et al. (2009) Evaluation of the Performance of CareStart Malaria Pf/Pv Combo and Paracheck Pf Tests for the Diagnosis of Malaria in Wondo Genet, Southern Ethiopia. Acta Tropica, 111, 321-324.
https://doi.org/10.1016/j.actatropica.2009.05.014

has been cited by the following article:

  • TITLE: Evaluation of Three Rapid Diagnostic Test Kits in the Diagnosis of Plasmodium Species Infections among Primary School Children in Baringo County, Kenya

    AUTHORS: Collince Jared Omondi, Lucy Muthony Kamau, Humphrey Kariuki Njaanake, Douglas Anyona, Daniel Onguru, Benson Estambale

    KEYWORDS: Rapid Diagnostic Tests, Microscopy, Malaria, Sensitivity, Specificity, Baringo

    JOURNAL NAME: Open Journal of Clinical Diagnostics, Vol.7 No.1, March 28, 2017

    ABSTRACT: Background: Due to the difficulty in implementing microscopy-based definitive diagnosis of malaria especially in resource-poor areas, rapid diagnostic test (RDT) kits as alternatives have been developed by different companies. Kits from different companies may differ in sensitivity and specificity. It is therefore imperative to conduct field evaluation of kits from different manufacturers before they are recommended for widespread use in diagnosis of malaria. The present study sought to evaluate the performance of malaria RDT kits from two manufacturers against microscopy in detection of Plasmodium spp. infections among primary school children in Baringo County, Kenya. Methods: Two cross-sectional comparative surveys to assess three RDT kits (CareStart HRP-2, SD Bioline Ag-Pf and SD Bioline Ag-Pf/Pan) were conducted on 561 pupils from three primary schools within the Kerio Valley of Baringo County, Kenya. Results: A total of 561 blood samples were tested for Plasmodium spp. within a period of four months. SD Bioline Ag-Pf/ Pan RDT kit had a higher sensitivity (90%) compared to that of CareStart HRP-2 (70%) but this was not statistically significant (McNemar’s χ2 = 0.5, df = 1, p = 0.4795). The sensitivity of SD Bioline Ag-Pf was the same as that of Care Start HRP-2 (82.4%). The number of positive samples by microscopy was relatively lower than those detected by RDT kits. Two cases of non-P. falciparum infections were detected by RDT kits during the second survey. Conclusion: The results of the present study suggest that the performance of the three kits in the diagnosis of P. falciparum infections was better than microscopy. The sensitivity of SD Bioline Ag-Pf/Pan was slightly greater than that of Care Start HRP-2, although not statistically different.