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https://doi.org/10.1038/83799

has been cited by the following article:

• TITLE: Regulation of Intestinal Cholesterol Absorption: A Disease Perspective

  AUTHORS: Jahangir Iqbal, Ali Al Qarni, Abbas Hawwari

  KEYWORDS: Cholesterol Absorption, Atherosclerosis, Metabolic Disease, NPC1L1, ATP-Binding Cassette Transporters

  JOURNAL NAME: Advances in Biological Chemistry, Vol.7 No.1, February 24, 2017

  ABSTRACT: Hypercholesterolemia promotes atherosclerosis and precise regulation of cholesterol homeostasis is essential. Besides risk factor for cardiovascular disease, abnormalities in cholesterol metabolism have been associated with type 2 diabetes. Cholesterol homeostasis in the body is maintained by de novo synthesis. Furthermore, intestinal cholesterol absorption has recently been considered as an important control point in cholesterol homeostasis. Important insights have been gained into the mechanisms of transport of cholesterol from the intestinal lumen into the enterocytes. Several transporter proteins that appear to be key players in the control of the cholesterol absorption from the intestinal lumen have been identified. Here, we review intestinal cholesterol absorption and the mechanisms underlying alterations in cholesterol absorption under physiological conditions and in diseases such as diabetes mellitus.