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Zuckerbraun, B.S., Stoyanovsky, D.A., Sengupta, R., Shapiro, R.A. and Ozanich, B.A. (2007) Nitric Oxide-Induced Inhibition of Smooth Muscle Cell Proliferation Involves S-Nitrosation and Inactivation of RhoA. American Journal of Physiology and Cell Physiology, 292, C824-C831.
https://doi.org/10.1152/ajpcell.00592.2005

has been cited by the following article:

  • TITLE: L-Arginine Levels among Hypertensive Patients in Sokoto, North Western Nigeria

    AUTHORS: O. Erhabor, A. B. Ibrahim, Y. Abdulrahaman, A. H. Chiroma, M. Imoru, F. P. Udomah, M. Ahmed, K. Ibrahin, H. Buhari, A. Okwesili, O. Onuigwe, H. M. Liman, K. Van Dyke, N. B. Egenti, I. P. Iwueke

    KEYWORDS: L-Arginine, Hypertensive Patients, Sokoto, Nigeria

    JOURNAL NAME: Open Journal of Blood Diseases, Vol.7 No.1, December 30, 2016

    ABSTRACT: Hypertension is a major public health problem that adversely affects the health status of individuals, families and communities. L-arginine levels of a total of 90 consecutively-recruited hypertensive subjects and 50 age-matched non-hypertensive controls were studied. Plasma from subjects and control participants were analyzed for L-arginine. The mean values of L-arginine level were significantly lower among the hypertensive subjects which are (174.33 ± 78.31 μmol/L) compared to those of the 50 non-hypertensive controls (237.82 ± 261.16 μmol/L) (p = 0.04). There was no statistically significant difference in the L-arginine levels of hypertensive subjects based on gender, age and ethnici-ty (p = 0.87, 0.23 and 0.57) respectively. The L-arginine level was significantly higher among married hypertensive subjects (181.71 ± 78.17 μmol/L) compared to single or unmarried subjects (130.62 ± 65.99 μmol/L) (p = 0.03). The mean value of L-arginine level was significantly higher among hypertensive subjects with mild blood pressure (187.63 ± 77.93 μmol/L) compared to those with high blood pressure (156.93 ± 76.31 μmol/L). The difference however was not statistically significant (p = 0.05). The findings from this study confirm that the level of L-arginine is lower among hypertensive subjects compared to non-hypertensive controls. Age, gender and ethnicity did not have a significant effect on the L-arginine levels of hypertensive subjects. L-arginine level was significantly lower among single hypertensive patients and those with markedly raised blood pressure. It is recommended the L-arginine supplement be prescribed to hypertensive patient as a prophylactic measure. There is a need to enlighten hypertensive patients in the area on the need to maintain a balanced diet containing sufficient level of L-arginine.