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Qi, P., Dou, T.H., Geng, L., Zhou, F.G., Gu, X., Wang, H. and Gao, C.F. (2010) Association of a Variant in MIR 196A2 with Susceptibility to Hepatocellular Carcinoma in Male Chinese Patients with Chronic Hepatitis B Virus Infection. Human Immunology, 71, 621-626.
https://doi.org/10.1016/j.humimm.2010.02.017

has been cited by the following article:

  • TITLE: The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies

    AUTHORS: Rongce Zhao, Jing Zhou, Fei Liu, Yonggang Wei, Kefei Chen, Bo Li

    KEYWORDS: miR-196a2, rs11614913, Polymorphism, Digestive System Cancers, Meta-Analysis

    JOURNAL NAME: Open Journal of Internal Medicine, Vol.6 No.4, November 30, 2016

    ABSTRACT: Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.