SCIRP Mobile Website
Paper Submission

Why Us? >>

  • - Open Access
  • - Peer-reviewed
  • - Rapid publication
  • - Lifetime hosting
  • - Free indexing service
  • - Free promotion service
  • - More citations
  • - Search engine friendly

Free SCIRP Newsletters>>

Add your e-mail address to receive free newsletters from SCIRP.


Contact Us >>

Article citations


Rosillo, M.A., Alcaraz, M.J., Sánchez-Hidalgo, M., Fernández-Bola?os, J.G., Alarcón-de-la-Lastra, C. and Ferrándiz, M.L. (2014) Anti-Inflammatory and Joint Protective Effects of Extra-Virgin Olive-Oil Polyphenol Extract in Experimental Arthritis. The Journal of Nutritional Biochemistry, 12, 1275-1281.

has been cited by the following article:

  • TITLE: Differential Anti-Inflammatory Effects of Three Purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse

    AUTHORS: Pamela Izaret Pérez-Martínez, Víctor Gabriel Hernández, Oscar Rodríguez-Espinosa, Patricia Arce-Paredes, Oscar Rojas-Espinosa

    KEYWORDS: Collagen, CIA, DBA-1 Mice, Omega-UFAs, Dexamethasone, Anti-Inflammatory

    JOURNAL NAME: Modern Research in Inflammation, Vol.5 No.3, August 2, 2016

    ABSTRACT: Background: The Mediterranean Diet (MD) has been linked to a reduced risk of developing degenerative diseases, including atherosclerosis, heart stroke, diabetes, arthritis and cancer. However, only a few scientific investigations have attempted to validate this impression. The ingredients of the MD include significant amounts of omega (ω3,ω6, andω9) unsaturated fatty acids (UFAs). A few studies of these UFAs in the prevention or treatment of arthritis have yielded controversial results, but a general belief regarding their beneficial effects has prevailed. Objective: To investigate the effects of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid (AA), and Oleic Acid (OA) (ω3,ω6, andω9, respectively), in the development of arthritis using a murine model of Collagen-Induced Arthritis (CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII) and were subsequently treated withω-UFAs for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory agent. The effect of the treatments was evaluated through several parameters: inflammation indices, antibody levels, cell prolifera- tion, and histopathological findings. Results and Conclusion: The anti-inflammatory effect of the tested substances was inversely correlated with the histopathological findings: a greater anti- inflammatory effect was associated with less articular damage. Oleic acid (ω9) was the most efficient anti-inflammatory UFA, followed by DHA and then AA. DEXA completely inhibited the development of arthritis, whereas the untreated CII-immunized mice developed the most severe articular damage. DBA-1 mice with CII-induced arthritis constitute an adequate model for the study of arthritis and its treatment.