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Article citations


Gardener, H., Wright, C.B., Cabral, D., Scarmeas, N., Gu, Y., Cheung, K., Elkind, M.S., Sacco, R.L. and Rundek, T. (2014) Mediterranean Diet and Carotid Atherosclerosis in the Northern Manhattan Study. Atherosclerosis, 2, 303-310.

has been cited by the following article:

  • TITLE: Differential Anti-Inflammatory Effects of Three Purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse

    AUTHORS: Pamela Izaret Pérez-Martínez, Víctor Gabriel Hernández, Oscar Rodríguez-Espinosa, Patricia Arce-Paredes, Oscar Rojas-Espinosa

    KEYWORDS: Collagen, CIA, DBA-1 Mice, Omega-UFAs, Dexamethasone, Anti-Inflammatory

    JOURNAL NAME: Modern Research in Inflammation, Vol.5 No.3, August 2, 2016

    ABSTRACT: Background: The Mediterranean Diet (MD) has been linked to a reduced risk of developing degenerative diseases, including atherosclerosis, heart stroke, diabetes, arthritis and cancer. However, only a few scientific investigations have attempted to validate this impression. The ingredients of the MD include significant amounts of omega (ω3,ω6, andω9) unsaturated fatty acids (UFAs). A few studies of these UFAs in the prevention or treatment of arthritis have yielded controversial results, but a general belief regarding their beneficial effects has prevailed. Objective: To investigate the effects of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid (AA), and Oleic Acid (OA) (ω3,ω6, andω9, respectively), in the development of arthritis using a murine model of Collagen-Induced Arthritis (CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII) and were subsequently treated withω-UFAs for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory agent. The effect of the treatments was evaluated through several parameters: inflammation indices, antibody levels, cell prolifera- tion, and histopathological findings. Results and Conclusion: The anti-inflammatory effect of the tested substances was inversely correlated with the histopathological findings: a greater anti- inflammatory effect was associated with less articular damage. Oleic acid (ω9) was the most efficient anti-inflammatory UFA, followed by DHA and then AA. DEXA completely inhibited the development of arthritis, whereas the untreated CII-immunized mice developed the most severe articular damage. DBA-1 mice with CII-induced arthritis constitute an adequate model for the study of arthritis and its treatment.