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Article citations


Zhu, Z.H., Yan, Y., Wang, Q.B., Qian, J.Y., Ge, J.B. (2010) Analysis of Serum Cardiac Biomarkers and Treadmill Exercise Test-Electrocardiogram for the Diagnosis of Coronary Heart Disease in Suspected Patients. Acta Biochimica et Biophysica Sinica, 42, 39-44.

has been cited by the following article:

  • TITLE: Analysis of Serum Biochemical Indexes for the Diagnosis of Coronary Heart Disease in Suspected Patients

    AUTHORS: Hongcheng Mai, Zhifeng Huang, Tao Zhang

    KEYWORDS: Treadmill Exercise Test, Coronary Angiography, Receiver Operating Characteristic, Glycated Hemoglobin, Coronary Heart Disease, Low-Density Protein

    JOURNAL NAME: Open Access Library Journal, Vol.3 No.3, March 2, 2016

    ABSTRACT: Background: The serum biochemical indexes are classic detection in clinical practice. Methods: In this study, for avoiding the risks of serious complications, high-cost in diagnosis of suspected coronary heart disease (CHD), the common biochemical indexes were detected from 68 eligible patients with suspected CHD. Treadmill exercises test (TET)-electrocardiogram (ECG) was measured during TET, and invasive examination of coronary angiography (CAG, golden standard for CHD diagnosis) was also performed. Results: For CAG, 48 patients were positive and 20 were negative; while for TET 38 were positive, 14 were inconclusive, and 16 were negative, respectively. Among these biochemical indexes, the HbA1c (%) level in CAG positive patients was much higher than that in CAG negative patients (P = 0.019). Furthermore, according to receiver operating characteristic (ROC) curve, HbA1c showed effective diagnosis for CHD and its best cutoff value was 5.85% and 29 of the patients were HbA1c positive and 30 were negative. Conclusions: It was found that HbA1c combined with TET obviously enhanced the sensitivity of examinations. All the patients who were negative in both HbA1c and TET tests turned out to be 90% CAG negative, which meant that the combination might stand invasive examination of CAG for CHD diagnosis. Further studies in multi-center investigation will be expected to validate the findings.