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Article citations


Helb, D., Jones, M. and Story, E. (2010) Rapid Detection of Mycobacterium tuberculosis and Rifampin Resistance by Use of On-Demand, Near-Patient Technology. Journal of Clinical Microbiology, 48, 229-237.

has been cited by the following article:

  • TITLE: The Prevalence of Drug-Resistant Tuberculosis among People Living with HIV (PLHIV) in Abia State

    AUTHORS: Onuka Okorie, Ahukanna John, M. Gidado, Gabriel Akang, Ubochioma Emperor, Enogu Rupert, Ibeziako Vivian, Emmanuel Meribole, Pius Osakwe

    KEYWORDS: Multidrug Resistant TB, among People Living with HIV

    JOURNAL NAME: Advances in Infectious Diseases, Vol.6 No.2, June 20, 2016

    ABSTRACT: Tuberculosis (TB) is a chronic disease caused by mycobacterium tuberculosis and transmittedfrom person to person, through inhalation of droplet nuclei aerosolized by coughing of an infectedperson. It reached epidemic proportions in Europe and North America during the 18th and 19thcenturies. The incubation period is 2 - 6 weeks and the control has been complicated with emergence of HIV and drug-resistant TB. In 1993, World Health Organization (WHO) declared TB aglobal emergency. However, despite the concerted effort of National TB control programs, adoption and implementation of Stop TB strategy, TB has remained a major public health challengewith high mortality rate, especially in developing countries. Methodology: This is a descriptivestudy, evaluated using the positivist/quantitative approach. The study was conducted at FederalMedical Centre Umuahia, a tertiary specialist hospital with comprehensive TB/HIV treatment services. All the presumptive drug-resistant TB cases and symptomatic PLHIV were screened for HIVand their sputum specimens were tested for tuberculosis using the Gene xpert and the Ziehl-Neelsen technique for detecting Acid Fast bacilli. A pretested structured questionnaire was used tocollect the demographic data and other essential data from the presumptive TB and laboratoryregisters such as total number of TB presumptive cases registered HIV status, AFB status and rifampicin status within the study period. Result: A total of 493 presumptive TB cases werescreenedin the study, 49.9% were HIV positive while 50.05% were HIV negative. More so, 77.85% of thescreened cases were AFB negative and 22.15% were AFB positive. Moreover, 11% of the TB/HIVco-infected patients were rifampicin positive. Interestingly among the 493 cases screened withgene xpert machine, 3.6% were rifampicin positive. Furthermore, 3.6% of the HIV negative cases were rifampicin positive while 1.6% of the HIV positive cases were rifampicin positive. Discussion: The data depict lower rifampicin resistance among HIV positive cases than HIV negative cases. The implication for public health professionals is to intensify equitable and unbiased search for resistant TB cases among smear negative and positive cases.