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Kim, C.H., Johnston, B. and Butcher, E.C. (2002) Trafficking Machinery of NKT Cells: Shared and Differential Chemokine Receptor Expression among Vα24+Vβ11+ NKT Cell Subsets with Distinct Cytokine-Producing Capacity. Blood, 100, 11-16.
http://dx.doi.org/10.1182/blood-2001-12-0196

has been cited by the following article:

  • TITLE: Human CD4- CD8- Invariant Natural Killer T Cells Promote IgG Secretion from B Cells Stimulated by Cross-Linking of Their Antigen Receptors

    AUTHORS: Tomomitsu Miyasaka, Yurie Watanabe, Yukiko Akahori, Namiko Miyamura, Keiko Ishii, Yuki Kinjo, Yoshitsugu Miyazaki, Tian-Yi Liu, Yasushi Uemura, Kazuyoshi Kawakami

    KEYWORDS: Invariant Natural Killer T Cells, TI-2 Antigen, B Cells, IgM, IgG

    JOURNAL NAME: World Journal of Vaccines, Vol.6 No.2, May 12, 2016

    ABSTRACT: Immunoglobulin (Ig) M production can be induced by the interaction of thymus-independent type-2 (TI-2) antigen (Ag) with B cell Ag receptors (BCRs) without the involvement of conventional T cells; for IgG production through the same process, however, a second signal is required. Previous studies have reported that invariant natural killer T (iNKT) cells may be responsible for the second signal involved in IgG production. In the present study, we addressed whether human iNKT cells could participate in the production of Ig against TI-2 Ag in vitro. Two major distinct subsets of human iNKT cells, CD4+ CD8β- (CD4) and CD4- CD8β- [double negative (DN)] cells, were generated from peripheral blood monocytes from a healthy volunteer. BCR engagement, triggered by anti-IgM antibody stimulation, examined here as a model of BCR engagement triggered by TI-2 Ag, induced abundant IgM production by B cells. Both CD4 and DN iNKT cells reduced IgM production and conversely enhanced IgG production in a dose-dependent manner. In addition, IgG production by CD19+CD27- (naïve) and CD19+CD27+ (memory) B cells was predominantly promoted by DNiNKT cells rather than CD4 iNKT cells; nevertheless, IgM production by both B cell subsets was similarly reduced by either subset of iNKT cells. These results suggest that the DN iNKT subsets may preferentially promote Ig class switching by B cells upon stimulation with TI-2 Ag.