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Lee, Y.C., Chen, T.H., Chiu, H.M., Shun, C.T., Chiang, H., Liu, T.Y., Wu, M.S. and Lin, J.T. (2013) The Benefit of Mass Eradication of Helicobacter pylori Infection: A Community-Based Study of Gastric Cancer Prevention. Gut, 62, 676-682.
http://dx.doi.org/10.1136/gutjnl-2012-302240

has been cited by the following article:

  • TITLE: Gastric-and-Intestinal Mixed Intestinal Metaplasia Is Irreversible Point with Eradication of Helicobacter pylori

    AUTHORS: Yuka Kiriyama, Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Mitsuru Nakagawa, Asako Okabe, Naoki Ohmiya, Makoto Kuroda, Atsushi Sugioka, Masao Ichinose, Masae Tatematsu, Tetsuya Tsukamoto

    KEYWORDS: Helicobacter pylori, Chronic Atrophic Gastritis, Intestinal Metaplasia, Eradication, Stomach

    JOURNAL NAME: Open Journal of Pathology, Vol.6 No.2, April 20, 2016

    ABSTRACT: Helicobacter pylori (H. pylori) represents an important factor in the development of atrophic gastritis, intestinal metaplasia (IM), and gastric cancer. Eradication of H. pylori has been reported to prevent gastric cancer only in cases without atrophy or IM. However, histological changes with eradication have yet to be fully clarified. We evaluated 38 H. pylori-positive cases before and after eradication at the gland level; pyloric glands were classified as showing gastric proper (G) and IM gland types, with the latter including gastric-and-intestinal mixed IM (GI-IM) and solely intestinal IM (I-IM), depending on the remaining gastric phenotypes. On eradication, acute and chronic inflammation attenuated rapidly and gradually, respectively, whereas levels of MUC5AC and MUC6 expression were not markedly altered. Gland width, size of nuclei and cytoplasm and their ratio in surface foveolar epithelium, the number of Ki-67-positive cells and the length of the proliferating zone in each gland were significantly decreased in G glands after eradication compared with those in GI-IM and I-IM. The number of mitotic phase cells, positive for phosphorylated histone H3 at serine 28, was increased in both types of IM compared to that in G glands in the H. pylori-infected state, but unexpectedly remained unchanged with eradication. These results suggest that GI-IM, as the beginning of IM, could represent a histological irreversible point with eradication and be considered as a “histological point of no return”.