TITLE:
Trend of Invasive Streptococcus agalactiae at Tertiary Care Hospital in Japan
AUTHORS:
Masaaki Minami, Hideki Nishiyama, Shinobu Ikegami, Takuya Hattori, Makoto Kawashima, Michio Ohta
KEYWORDS:
Streptococcus agalactiae, Susceptibility, Antimicrobial Resistance, Epidemiology
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.3,
February
26,
2016
ABSTRACT:
Streptococcus agalactiae causes
various severe infectious diseases such as sepsis, meningitis, and
streptococcal toxic shock-like syndrome. Though Streptococcus agalactiae infection
has been increasing recently, the comprehensive characteristic investigation of
invasive Streptococcus agalactiae isolated in tertiary care hospitals has not
been nearly performed in Japan. In this study, we investigated the clinical
characteristics and antimicrobial susceptible patterns of 88 Streptococcus
agalactiae isolated at two tertiary care hospitals during 2009-2015 in Japan.
There was no significant differences between genders in our study. Two-third
Streptococcus agalactiae were isolated from over age 60. Total mortality rate
was 19% and invasive Streptococcus agalactiae-associated death cases have
occurred every year after 2011. All Streptococcus agalactiae were completely
susceptible toampicillin. Total non-susceptible rates of erythromycin,
minocycline, levofloxacin and trimethoprim-sulfamethoxazole in this study were
approximately 30%, 44%, 37%, and 7%, respectively. Our results suggest the need
for continuous antimicrobial susceptibility survey of Streptococcus agalactiae.